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Gao Yue-lin , Duan Yu-hong "A New Particle Swarm Optimization Algorithm with Random Inertia Weight and Evolution Strategy" International Conference on Computational Intelligence and Security Workshops 2007. Guimin Chen, Xinbo Huang, Jianyuan Jia and Zhengfeng Min " Natural Exponential Inertia Weight Strategy in Particle Swarm Optimization" 6th World Confress on Intelligent Control and Automation, June 21 - 23, 2006, Dalian, China. Jong-Bae Park, Yun-Won Jeong, Hyun Houng Kim and Joong-Rin Shin "An Improved Particle Swarm Optimization for Economic Dispatch with Valve-Point Effect" International Journal of Innovations in Energy Systems and Power, Vol. Therefore by emphasizing this protein as a drug target can help in the identification of novel drugs to cure leprosy. Black PN, Zhang Q, Weimar JD, Di Russo CC (1997): Mutational analysis of a fatty Acyl-coenzyme A Synthetase signature motif identifies seven amino acid residues that modulate fatty acid substrate specificity. Key words: cellular genetic algorithm, dynamic optimization, density dependence scheme Reference [1] R. The activation of fatty acids by Acyl-Co A Synthetase is the need of de novo lipid biosynthesis, fatty acid catabolism and remodeling of biological membranes. The computation results indicate that new algorithms demonstrate their superiority respectively on both convergence and diversity. Conventional hydraulic cylinders are simulated in FLUENT. Singh, "Derivation of design requirements for optimization of a high performance hydrostatic actuation system," International Journal of Fluid Power, vol. Results show that the small outlet ports are the sources of energy loss in hydraulic cylinders. Biologically inspired evolutionary agent systems in dynamic environments. Diversity-based model reference for genetic algorithms in dynamic environment. The bacteria have developed resistance against many of the drugs available in the market.

The study investigates and analyzes the possibilities of reducing the hydraulic resistance and increasing efficiency of the hydraulic actuator.

Key words: docking, homology modeling, leprosy, M.leprae, molecular, molecular dynamics, ramachandran plot.

Therefore identification of the novel drug target and potent drug can be helpful in better prevention of the disease. Alter, (2008) Leprosy as a genetic model for susceptibility to common infectious disease, Hum Genet 2. (1999)Health Policy and Planning; 14(2): 89-102, Oxford University Press.

Abstract: Particle swarm optimization (PSO ) is an effective & reliable evolutionary based approach .

Yuhui Shi and Russell Eberhart "A modified particle swarm optimizer" 0- 7803-4869-9198 0.0001998 IEEE.

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